Current and Recent Federal, Foundation and Industry Funded Grants



Federal Grants


Dr. Barrett


VPSD                                                        Barrett (Scholar)                     07/01/08 - 05/31/10

Vanderbilt University Physician Scientist Development Program Award                      

A Randomized, Double Blind, and Placebo-Controlled Trial Comparing Ondansetron, Metoclopramide and Promethazine for Treatment of Nausea and Vomiting in the Adult Emergency Department

The goal of this study is to determine whether ondansetron has superior nausea reduction compared to metoclopramide, promethazine, or saline placebo in emergency department adults with undifferentiated nausea.


NIH/NHLBI  K23-HL-102069                     Barrett (PI)         06/01/2010-09/30/2015

Improving Atrial Fibrillation Risk Stratification in the ED

The goal of this study is to develop and validate a multivariable clinical prediction rule that accurately estimates risk for adverse outcome in emergency department patients with atrial fibrillation.  We will describe and analyze the rule’s utility by the distribution of assigned risk and its impact on physician decision-making. 




Dr. Collins


PCORI FC14-1409-21656                     Collins (PI)                          10/15/2015-10/14/2018       

GWTG Interventions to Reduce Disparities in Acute HF Patients Discharged  from  the ED (GUIDED HF)                          

The project will evaluate the benefits of a Get With the Guidelines-HF based, tailored transitional care intervention for acute heart failure patients scheduled for discharge after a bried period of observation from the emergency department.


NIH/NHLBI K12 HL109019-02             Storrow (PI); Collins (co-PI)                   07/01/2011-06/30/2016

The Vanderbilt Emergency Medicine Research Training Program” Career development program for emergency medicine


NIH/NHLBI (R01-HL-088459)                Storrow (PI); Collins (Co-I) 2007-2011

Improving Heart Failure Risk Stratification in the ED (STRATIFY)

The purpose of this study was to develop and validate a prediction rule for ED patients with signs and symptoms of acute heart failure.


NIH / NHLBI (K23-HL-085387)                 Collins (PI)          2008-2014

Treatment Endpoints in Acute Decompensated Heart Failure (DECIDE)

The goal of this project was to develop a prediction rule from readily available clinical data to help physicians identify patients with acute heart failure eligible for safe and early discharge from the ED and hospital after treatment is initiated.




Dr. Han

NIH / NHLBI K12HL109019    Storrow (PI); Han (Scholar)                2011 – 2016

“The Vanderbilt Emergency Medicine Research Training Program” Career development program for emergency medicine.

Dr. Han is a part of a career development program (K12) sponsored by the National Heart, Lung, and Blood Institute.  As part of this K12 program, he is determining how cognitive impairment (delirium and dementia) effects 30-day resource utilization.   


NIA / NIA K23AG032355           Han (PI)                                          2010 - 2015

Delirium in the Emergency Department: Novel Screening and Natural Course

This is a career development award (K23) from the National Institute on Aging to validate novel and brief delirium assessments specifically tailored for the busy emergency department environment.  This grant also sought to characterize the natural course of delirium in the emergency department and determine how its persistence into hospitalization effects 6-month function. 


Dr. Gupta

NHLBI      K12HL109019           Storrow (PI), Gupta (scholar)                       2011-2016

The Vanderbilt Emergency Medicine Research Training Program (VEMRT)

The Major Goal of this project is to train a new generation of scientists to address the compelling public health challenges in the management of acute heart, lung, blood, and traumatic diseases.

NHLBI K23HL128928                Gupta (PI)                                               2016-2020

The natriuretic peptide system in African-Americans. The major goal of this career development award is for the principal investigator to acquire the skills and unique expertise needed to transition into an independent investigator. During the course of the award, the PI will (1) assess the natriuretic peptide response to dietary salt loading in African-American individuals compared with white individuals and (2) examine the genetic basis for natriuretic peptide levels in African-Americans.



Dr. McNaughton


NIH/NHLBI K23HL125670                McNaughton (PI)                                  2015-2018

A Randomized, ED-based Intervention to Improve Antihypertensive Adherence

This 3-year grant develops and tests an ED-based behavioral intervention aimed at improving antihypertensive adherence at 30 and 90 days among 350 primary care patients with hypertension who seek ED care.



NIH/NHLBI K12 HL109019     Storrow (PI); McNaughton (Scholar)                             2012-2015

The Vanderbilt Emergency Medicine Research Training Program (VEMRT)

During the K12 fellowship, Dr. McNaughton published 22 peer-reviewed manuscripts, presented at 6 national meetings, and completed qualifying requirements for the Vanderbilt University Epidemiology doctoral program.



Dr. Muñoz

NHLBI      K12HL109019           Storrow (PI), Muñoz (scholar)                     2013-2016

The Vanderbilt Emergency Medicine Research Training Program (VEMRT)

During the K12 fellowship, Dr. Muñoz played a key role in the ongoing preparation of an R01 application to the NHLBI that seeks to identify novel strategies in the ED-based evaluation of patients with low-risk chest pain. The K12 also supported his development and participation in the team-based science outline below.

PCORI                         Muñoz (Site Co-PI)                                                  2015-1018

Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE)

Goal: To identify the optimal dose of aspirin in a high-risk secondary prevention population of patients with coronary heart disease



Dr. Self


NIH / NIGMS K23GM110469            Self (PI)                                           2015 – 2019

Salivary Cortisol as a Marker of Community-Acquired Pneumonia Severity in Adults.

This is a career development award (K23) from the National Institute of General Medical Sciences (NIGMS) to investigate how a novel biomarker, salivary cortisol, can improve a clinician’s ability to understand a patient’s risk for severe pneumonia-related outcomes.


NIH / NHLBI U01 HL123033            Rice (PI); Self (Co-PI)                                2014 - 2021

Clinical Coordinating Center for the Prevention and Early Treatment of Acute Lung Injury (PETAL) Clinical Trials Network.

In the NHLBI PETAL Network, we develop and conduct randomized controlled trials to prevent, treat, and improve the outcomes of patients with or at risk for acute lung injury. This network builds on the strengths and experiences of the successful ARDS Network, and shifts the focus of interventions toward prevention and earlier treatment of lung injury.


NIH / NCATS KL2TR000446             Bernard (PI); Self (Scholar)                      2012 – 2014

Multicenter implementation and evaluation of a quality improvement program to reduce blood culture contamination in the emergency department.    

This was a KL2 mentored career development award funded through the Vanderbilt Clinical and Translation Science Award (CTSA) to evaluate the effectiveness of a quality improvement toolkit for reducing blood culture contamination in community hospital emergency departments (Acad Emerg Med 2014; 21:274-282).



Dr. Ward


NIH / NHLBI K12HL109019             Storrow (PI); Ward (Scholar)                          2011 – 2016

“The Vanderbilt Emergency Medicine Research Training Program” Career development Program for Emergency Medicine.

Dr. Ward was a part of a career development program (K12) sponsored by the National Heart, Lung, and Blood Institute.  As part of this K12 program, he examined the timeliness of acute coronary syndrome, and heart failure treatment in the emergency department.



NIH / NHLBI K23HL127130 (NHLBI)      Ward (PI)                                           2016 - 2019

Enhancing Inter-Facility Transfer for Patients with Acute Myocardial Infarction

This is a career development award (K23) from the National Heart Lung and Blood Institute (NHLBI) to investigate of timeliness of inter-facility transfer for patients with ST-elevation myocardial infarction. This work focuses on understanding how facilities transfer patients and

how coordination affects timeliness.



Dr. Yiadom


NIH / NHLBI K12HL109019    Storrow (PI); Yiadom (Scholar)                   2014-2016

Improving the Screening Criteria for an Early ECG to Diagnose STEMI

Dr. Yiadom is investigating methods to improve screening for an early ECG to diagnose STEMI. Earlier diagnosis and treatment is associated with reduced mortality and better outcomes. As a result the goal is to obtain an early ECG within 10 minutes of arrival. However, the criteria used to identify which arriving patients get an early ECG are highly variable across EDs. This study hypothesis is that facility, patient population, and screening process characteristics influence the performance of ED screening criteria. This information can be used to better tailor STEMI screening criteria to avoid delays in STEMI diagnosis.






Dr. Collins


Rehn Family Grant                            Collins (PI)                                      2008-2009

The Association of CD 14 Levels with the Development of Abdominal Aortic Aneurysm

The goal in this grant was to investigate the relationship of serum CD 14 levels with human abdominal aortic aneurysm (AAA) and to characterize CD 14 expression in human AAA tissues.


University of Cincinnati Dean’s Discovery Fund     Collins (PI)                           2005-2006

Identifying Treatment Variables Associated with Subsequent Adverse Events in Decompensated Heart Failure: A Pilot Study

The major goal of this study is to test the feasibility of collecting prospective data and identify predictors of adverse events in the first 24 hours of therapy in ED heart failure patients.


Emergency Medicine Foundation Acute Heart Failure   Storrow (PI); Collins (Co-I)   2003

Emergency Department Observation Versus Inpatient Admission for Therapy of Acute Congestive Heart Failure

The major goal of this pilot project was to address the identification and cost analysis issues surrounding Observation Unit management of CHF so that initial treatment and appropriate disposition can be facilitated.




Dr. Self


Society for Academic Emergency Medicine               Self (PI)                   2011 – 2012

A patient safety initiative to minimize blood culture contamination in the ED.

This multicenter quality improvement study was funded by the Patient Safety Research Fellowship Grant from the Society for Academic Emergency Medicine and Emergency Medicine Patient Safety Foundation.  We evaluated the effectiveness of a quality improvement toolkit for reducing blood culture contamination in community hospital emergency departments (Acad Emerg Med 2014; 21:274-282).




Dr. Ward

Emergency Medicine Foundation              Ward (PI)                                2011 – 2013

Going Paperless: Understanding Emergency Department Operational Performance During Electronic Health Record Implementation. 

This was a research fellowship award from the Emergency Medicine Foundation. This study examined operational disruption of emergency department performance caused by electronic health record implementation.








Dr. Barrett


RIVAROXAFL4002                                       Barrett (Site PI)                   06/01/2014-05/30/2016

Janssen Scientific Affairs, LLC                                                               

This prospective registry, Phase II of the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF II), is designed to evaluate the utilization of target-specific antithrombotic agents, such as factor Xa (FXa) inhibitors and direct thrombin inhibitors, and associated outcomes.


Alere                                                Barrett (Site PI)                                     2015-2016


This study investigated the performance of multiple point-of-care INR platforms in patients with supratherapeutic INRs. 



Dr. Collins


Novartis                      Collins (Co-PI; Executive Director - DCC)                     2014-ongoing

EMROC (Emergency Medicine Research and Outcomes Consortium)   

This is a network of acute heart failure ED researchers which is developing a large registry of ED patients with acute heart failure for the purposes of describing patterns in early management decisions.


Novartis                      Collins (PI)                                              4/15/2016-3/1/2017

Identifying Diuretic Resistance in Patients with Acute Heart Failure  

This study evaluates early urinary sodium to identify patients who will develop diuretic resistance.


Inovise Medical, Inc.                   Collins (PI)                                                     2005 – 2006

HEart failure and Audicor technology for Rapid Diagnosis and Initial Treatment: HEARD-IT Trial

The major goal of this international, multi-center industry sponsored study was to compare 15 minute emergency department diagnostic accuracy with the 15 minute diagnostic accuracy of the Audicor S3 heart sound data in patients presenting to the Emergency Department with dyspnea.



Dr. Gupta


Novartis                      Gupta (Site PI)                    2015-2021                  

PARAGON HF - a multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of LCZ696.

The major goal of this study is to test the hypothesis that LCZ696 is superior to valsartan alone in reducing heart failure hospitalizations or cardiovascular death in patients with heart failure and preserved ejection fraction. 



Dr. Han

Novartis Inc.                                 Han (Vanderbilt site-PI)                      2015 – 2021

International Registry to Assess Medical Practice with Longitudinal Observation for Treatment of Heart Failure (REPORT-HF)

This is a global, multicenter, prospective cohort study that will enroll 20,000 patients with acute heart failure. This study seeks to characterize acute heart failure therapy patterns during hospitalization and post-discharge events such as healthcare resource utilization and quality of life. 


Novartis Inc.                                 Han (Vanderbilt site-PI)                      2015 – 2017

A multicenter, randomized, double-blind, placebo controlled phase IIIb study to evaluate the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients.

The purpose of this study is to evaluate the efficacy, safety and tolerability of intravenous infusion of serelaxin when added to standard therapy in approximately 6,800 acute heart failure (AHF) patients. Efficacy will be determined based on the relative reduction in cardiovascular death, worsening heart failure and other clinical outcomes through a follow-up period of 180 days, as compared to placebo.




Dr. Self


BioAegis, Inc                                 Self (PI)                                           2014 – 2016

Evaluation of plasma gelsolin as a marker of clinical outcomes and etiology in adults hospitalized with community-acquired pneumonia.

This is an investigator-initiated, industry-sponsored multicenter study to evaluate plasma gelsolin as a marker of disease severity and etiology in adults with community-acquired pneumonia.


Pfizer                                     Self (Vanderbilt site-PI)                       2013 – 2016

Streptococcus pneumoniae serotypes in adults 18 years and older with radiographically-confirmed community-acquired pneumonia (CAP) [Pfizer protocol: B1851147].

This was a multicenter prospective cohort study to determine the prevalence of pneumococcal serotypes in adults with community-acquired pneumonia in the United States.


Rapid Pathogen Screening, Inc.         Self (Vanderbilt site-PI)                                      2014 – 2016

Clinical performance of FebriDx in patients being evaluated for acute community acquired febrile respiratory infection (protocol #: 13-0830).

This is a multicenter prospective study to evaluate the accuracy of a novel point-of-care biomarker panel for distinguishing between bacterial and viral respiratory infections.


BRAHMS GmbH / Thermo Fisher    Self (Vanderbilt site-PI)                                      2013 – 2014

Procalcitonin decrease over 72 hours and outcome in patients with severe sepsis or septic shock.

This was a multicenter prospective cohort study to evaluate the predictive performance of changes in procalcitonin levels for clinical outcomes in severe sepsis.




Dr. Ward


Abbott Point of Care, Inc.                             Ward (Site PI)                                   2014 - 2015

Cost-Effectiveness Analysis of Point of Care Lactate Testing to Identify Severe Sepsis in the Emergency Department.

This study was an investigator-initiated cost-effectiveness analysis of point of care testing for patients with severe sepsis presenting to the emergency department.